The Great River Road has many routes in, around, and across St. Louis, and they’re all so poorly marked that you’re sure to get lost trying to follow any of them. From Alton, US-67 crosses just below Lock and Dam No. 26, taking first the Clark Bridge (over the Mississippi) and then the Lewis Bridge (over the Missouri River). No prizes for guessing what those names refer to, since coming from the north you enter the city on Lewis and Clark Boulevard (Hwy-367).
A good main non-freeway route across St. Louis is Kings Highway, which runs north-south past many of the city’s main destinations, including Forest Park and the Missouri Botanical Garden, before ending up at Gravois Avenue, part of old Route 66. From here, numerous roads give direct access to I-55 and US-61, both of which link up with the scenic GRR route south to Sainte Genevieve.