US-50 is now submerged beneath the Interstates and runs west–east around Kansas City via I-35, I-435, and I-470. The older, pre-Interstate route also avoided downtown, following what’s now signed as US-169 along Park Avenue and 47th Street, past the Country Club Plaza and the Nelson-Atkins Museum of Art, before dipping south again on the Swope Parkway to Lee’s Summit, where the old alignment rejoins the current US-50 routing.
To reach the downtown area from US-50, you can follow any of many north–south streets, like Troost Avenue, the down-at-heel old main drag, or the parkway-like El Paseo.